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ABA BasicPharmacology
1:24

A 34-year-old patient undergoing general anaesthesia develops masseter muscle rigidity and rapid end-tidal CO₂ rise after succinylcholine. Core temperature rising 1°C / 5 min. Most appropriate immediate intervention?

AAdminister IV propofol and increase volatile agent
BDiscontinue triggering agents and give IV dantrolene 2.5 mg/kg
CApply surface cooling and administer IV beta-blockers
DDeepen anaesthesia and monitor for spontaneous resolution
Teaching Point
Malignant hyperthermia, a pharmacogenetic disorder triggered by volatile anaesthetics and succinylcholine. Dantrolene (ryanodine receptor antagonist) is the only specific treatment. Give 2.5 mg/kg IV, repeat every 5 min up to 10 mg/kg.
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